The index closed 8.73 points higher after gaining 2.71 points on Tuesday.
Trading on the Ho Chi Minh Stock Exchange (HoSE) fell by 5.1% to VND20.87 trillion ($864.09 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 22 tickers gain.
SSI of leading brokerage SSI Securities Corporation led with a 3.6% increase, followed by FPT of IT giant FPT Corporation, up 3.2%.
TPB of private TPBank went up 2.9% and CTG of state-owned lender VietinBank closed 2.7% higher.
Six blue chips fell. VIC of private conglomerate Vingroup dropped 2.2% and SSB of Southeast Asia Commercial Bank (SeABank) closed 0.9% lower.
Foreign investors were net buyers to the tune of VND523.86 billion, mainly buying KDC of food producer KIDO Group and CTG.
The HNX-Index at the Hanoi Stock Exchange, where mid and small caps list, was up 0.60% while the UPCoM-Index at the Unlisted Public Companies Market was up by 0.35%.