The index closed 10.18 points lower after dropping 9.59 points in the previous session.
Trading on the Ho Chi Minh Stock Exchange increased by 7% to VND15.854 trillion (US$626 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 24 tickers fell.
TPB of private TPBank slid 2.9%, GVR of Vietnam Rubber Group dropped by 2.3%, and VPB of private lender VPBank closed 2.2% lower.
Four blue chips gained. BVH of insurance company Bao Viet Holdings closed 0.5% higher, SAB of brewer Sabeco went up 0.4% and CTG of state-owned lender VietinBank saw a 0.3% increase.
Foreign investors were net seller to the tune of VND673 billion, mainly selling MSN of conglomerate Masan Group and VHM of property giant Vinhomes.
The HNX-Index for stocks on the Hanoi Stock Exchange, home to mid and small caps, fell 0.42%, while the UPCoM-Index for the Unlisted Public Companies Market went down 0.40%.
Globally, MSCI's broadest index of Asia-Pacific shares outside Japan rose 0.6% on Monday, recovering from its fall to a five-week low on Friday, Reuters reported.
Chinese blue-chip stocks gained 1.4%, with the Shanghai Composite Index up 1.2%.
European stocks were flat in early trading, with British shares the outlier, adding 0.4%.
Wall Street was heading for slim gains, with Nasdaq futures rising 0.2% and S&P 500 futures up 0.1%.