The index closed 0.23 points lower after gaining 11.79 points in the previous session.
Trading on the Ho Chi Minh Stock Exchange increased by 5% to VND12.757 trillion (US$501.8 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 11 tickers fell.
VHM of property giant Vinhomes slipped 3.9%, STB of HCMC-based lender Sacombank dropped 1.2%, and SSI of brokerage SSI Securities Corporation went down 1.0%.
Thirteen blue chips gained. GAS of state-owned Petrovietnam Gas saw the biggest increase of 1.5%, followed by TCB of private lender Techcombank with a 1.3% gain, and HPG of steelmaker Hoa Phat Group, up 1.0%.
Foreign investors were net buyers to the tune of VND31 billion, mainly buying HDG of construction firm Ha Do Group and TCB.
The HNX-Index for stocks on the Hanoi Stock Exchange, home to mid and small caps, fell 0.21%, while the UPCoM-Index for the Unlisted Public Companies Market went up 0.13%.
Globally, tech shares led gains in Europe on Friday, with the benchmark stock index hitting a one-week high and on track for its first weekly advance in five, as the recent selling pressure driven by geopolitical tensions came to a halt, Reuters reported.
The pan-European STOXX 600 was up 0.6%, set for its second day of gains following a four-day losing streak as rising uncertainty around the Ukraine-Russia conflict boosted demand for safe-haven assets.
The STOXX 600, however, eyed weekly gains after losing over 4% in the past four weeks.
Tech hit a one-week high, up 1%, led by chip stocks. The sector ended Thursday higher, reversing early losses after U.S.-based Nvidia's overnight revenue forecast.