The index closed 6.23 points lower after gaining 5.75 points in the previous session.
Trading on the Ho Chi Minh Stock Exchange decreased by 24% to VND11.693 trillion (US$473.7 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 23 tickers fell.
VIC of private conglomerate Vingroup saw the biggest drop of 2.13%, followed by VHM of property giant Vinhomes with a 2.05% decline and BVH of insurance company Bao Viet Holdings, down 1.8%.
Only three blue chips gained. HPG of steelmaker Hoa Phat Group went up 0.8%, GAS of state-owned Petrovietnam Gas grew 0.7%, and SSB of lender SeABank closed 0.6% ghigher.
Foreign investors were net seller to the tune of VND484 billion, mainly selling FPT of IT giant FPT Corporation and HPG.
The HNX-Index for stocks on the Hanoi Stock Exchange, home to mid and small caps, fell 0.51%, while the UPCoM-Index for the Unlisted Public Companies Market went down 0.41%.
Globally, Asian share markets slipped on Monday as worries about U.S. and Chinese growth weighed on sentiment, Reuters reported.
Chinese blue chips dropped 1.0% to seven-month lows, having already shed 2.7% last week.
Japan's Nikkei bore the brunt of the early selling as tech stocks declined, losing another 0.8% on top of a near 6% slide last week.
MSCI's broadest index of Asia-Pacific shares outside Japan slipped 1.2%, after shedding 2.25% last week, while South Korea's market fell 0.2%.
Data on consumer prices (CPI) from China showed the Asian giant remained a driver of global disinflation, with producer prices falling an annual 1.8% in August when analysts had looked for a drop of 1.4%.