The index closed 2.14 points lower after dropping 2.91 points in the previous session.
Trading on the Ho Chi Minh Stock Exchange increased by 30% to VND18.52 trillion ($728 million).
Foreign investors net bought VND6 billion, with a focus on HDB of HDBank and STB of Ho Chi Minh City-based lender Sacombank.
The VN-30 basket, comprising the 30 largest capped stocks, saw 22 tickers fell.
TCB of the largest private lender Techcombank dropped 1.5%, followed by MSN of conglomerate Masan Group, down 1.3%.
BVH of insurance company Bao Viet Holdings declined by 1.1% and BCM of Becamex Investment and Industrial Development closed 0.9% lower.
Eight blue chips gained, led by HDB of HDBank with a 1.4% increase. SSI of leading brokerage SSI Securities Corporation closed 1.3% higher.
The HNX-Index for stocks on the Hanoi Stock Exchange, home to mid and small caps, rose 0.35%, while the UPCoM-Index for the Unlisted Public Companies Market went down 0.38%.