"We now expect the (British) economy to enter a mild recession by early 2017," Goldman economist Jan Hatzius and Sven Jari Stehn wrote in a note for clients.
They expect the victorious "leave" outcome in the June 23 referendum to chop a cumulative 2.75 percent off UK gross domestic product in the next 18 months.
They also expect knock-on effects in the U.S. and European economies.
Goldman now expects eurozone GDP over the next two years to average 1.25 percent versus 1.5 percent before the Brexit vote.
For the U.S. economy, the bank now expects GDP growth in the second half of 2016 to come in at 2 percent versus a forecast of 2.25 percent previously.
Goldman sees three principle risks for as a result of the vote: terms of trade are likely to deteriorate; companies are likely to scale back investment due to the uncertainty created by the outcome; and financial conditions will tighten due to exchange rate fluctuations and weakness in risk assets like stocks and junk bonds.
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