The four members of the band will arrive in Hanoi to perform at the HAY Glamping Music Festival on August 6.
They are expected to perform some of their hits from the 1990s and 2000s.
The Moffatts said: "Vietnam is a very beautiful country. We have come here to perform and had great experiences with delicious food and friendly people.
"We want to become tourists and promote Vietnam's beauty through the journey."
Formed in 1990 the band comprises brothers Scott, Clint, Bob, and Dave Moffatt and has nearly 3.9 million followers on its YouTube channel.
In 1999 they had performed in Ho Chi Minh City.