In a communiqué sent to all 63 cities and provinces Wednesday, he said all adults should be immunized by the end of the first quarter of this year.
He also called for administering the second dose to everyone aged 12 to 18 this month.
All localities must continue with their campaigns to encourage people to get vaccinated and programs to send medical workers to vaccinate bedridden patients.
Around 75.4 million out of Vietnam's 96 million people have been given two doses, including 8.1 million children aged less than 18.
Besides, 22.39 million adults have gotten a third shot.