Yoon will address the general assembly of the International Bureau of Expositions (BIE), the organizer of the world fair, to promote South Korea's bid. The meeting runs from June 20-21.
The southeastern South Korean city of Busan faces competition from Saudi Arabia's Riyadh, Italy's Rome and Ukraine's Odesa for the global event. The host country for the 2030 expo is expected to be decided in November.
Yoon will meet with French President Emmanuel Macron on Tuesday.
The two leaders last met in June 2022 in Madrid on the sidelines of a NATO summit and agreed to expand cooperation in the space and nuclear energy sectors.
Yoon will then head to Vietnam on Thursday for a three-day state visit, accompanied by a 205-person business delegation, his office said.
Yoon, who calls himself "the No. 1 salesman" for South Korea, has made business deals and "sales diplomacy" a core element of his foreign trips since taking office.
"It will be the largest business delegation since the launch of the Yoon Suk Yeol administration," Choi Sang-mok, senior presidential secretary for economy, said on Tuesday.