The index closed 1.23 points higher after gaining 10.49 points on Tuesday.
Trading on the Ho Chi Minh Stock Exchange (HoSE) increased by 15.6% to VND18.08 trillion ($769.85 million), one of the highest trading values recorded since the end of January.
The VN-30 basket, comprising the 30 largest capped stocks, saw 11 tickers gain.
NVL of property developer Novaland Group led with a 7% surge, followed by PDR of Phat Dat Real Estate Development, up 6.7%.
HPG of steelmaker Hoa Phat Group closed 3.9% higher and MSN of conglomerate Masan Group went up 2.6%.
Sixteen blue chips fell.
VCB of state-owned lender Vietcombank dropped 2% and GVR of Vietnam Rubber Group closed 1.1% lower.
Foreign investors were net sellers to the tune of VND163.29 billion, mainly selling VNM of dairy giant Vinamilk.
The HNX-Index at the Hanoi Stock Exchange, where mid and small caps list, was up 0.7% while the UPCoM-Index at the Unlisted Public Companies Market was up by 0.15%.