The index closed 14.21 points lower after dropping 18.22 points in the previous session.
Trading on the Ho Chi Minh Stock Exchange increased by 47% to VND14.88 trillion ($605.74 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 20 tickers fell.
MWG of electronics retail chain Mobile World plunged 6.9%, followed by SAB of brewer Sabeco, down 6.75.
SSI of leading brokerage SSI Securities Corporation dropped 6.4% and GVR of Vietnam Rubber Group closed 6.1% lower.
Ten blue chips gained, led by SSB of Southeast Asia Commercial Bank (SeABank) with a 1.8% increase.
Foreign investors were net buyers to the tune of VND305 billion, mainly buying HPG of steelmaker Hoa Phat Group and PVD of PetroVietnam Drilling & Well Services Corporation.
The HNX-Index for stocks on the Hanoi Stock Exchange, home to mid and small caps, droped 2.45% while the UPCoM-Index for the Unlisted Public Companies Market fell 1.64%.