The index closed 1.75 points lower after losing 0.45 points on Thursday.
Trading on the Ho Chi Minh Stock Exchange (HoSE) increased by 69% to VND22.43 trillion ($953.35 million), highest in six sessions.
The VN-30 basket, comprising the 30 largest capped stocks, saw 20 tickers fall.
PLX of fuel distributor Petrolimex lost 2.9%, followed by PDR of Phat Dat Real Estate Development with a 2.6% drop.
SAB of brewer Sabeco fell 2.5% and NVL of property developer Novaland Group lost 2.3%.
Eight blue chips gained, led by STB of Ho Chi Minh City-based lender Sacombank with a 4.3% rise.
Foreign investors were net buyers to the tune of VND466.00 billion, mainly buying VND of brokerage VNDirect and HPG of steelmaker Hoa Phat Group.
The HNX-Index at the Hanoi Stock Exchange, where mid and small caps list, was down 0.47% while the UPCoM-Index at the Unlisted Public Companies Market was up by 0.08%.