The index closed 11.41 points lower after losing 5.15 points on Thursday.
Trading on the Ho Chi Minh Stock Exchange (HoSE) increased by 16.52% to VND13.33 trillion ($568.56 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 24 tickers fell.
PDR of Phat Dat Real Estate Development and TCB of the largest private lender Techcombank both lost 4.3%.
GVR of Vietnam Rubber Group fell 4.1% and STB of Ho Chi Minh City-based lender Sacombank lost 2.8%.
Three blue chips gained: HPG of steelmaker Hoa Phat Group went up 1%, VRE of retail real estate arm Vincom Retail rose 0.7% and VCB of state-owned lender Vietcombank closed 0.2% higher.
Foreign investors were net sellers to the tune of VND216.44 billion, mainly withdrawing from STB of Ho Chi Minh City-based lender Sacombank and VND of brokerage VNDirect.
The HNX-Index at the Hanoi Stock Exchange, where mid and small caps list, was down 1.23% while the UPCoM-Index at the Unlisted Public Companies Market was down by 0.83%.