The index closed 1.24 points lower after gaining 7.87 points on Thursday.
Trading on the Ho Chi Minh Stock Exchange (HoSE) increased by 13.82% to VND13.36 trillion ($568.99 million).
Foreign investors were net buyers to the tune of VND1 trillion thanks to a VND1.3-trillion purchase into STG of transportation and warehousing firm South Logistics Jsc.
The VN-30 basket, comprising the 30 largest capped stocks, saw 16 tickers lose.
VHM of property giant Vinhomes dropped 1.6%, followed by VIC of private conglomerate Vingroup with a 1.3% decline.
BVH of insurance company Bao Viet Holdings and MSN of conglomerate Masan Group both lost 1.1%.
Thirteen blue chips gained, led by GVR of Vietnam Rubber Group with a 2.5% increase.
STB of Ho Chi Minh City-based lender Sacombank closed 2.4% higher.
The HNX-Index at the Hanoi Stock Exchange, where mid and small caps list, was up 0.42% while the UPCoM-Index at the Unlisted Public Companies Market was up by 0.21%.