The index closed 12.84 points lower after losing 2.94 points on Thursday.
Trading on the Ho Chi Minh Stock Exchange (HoSE) increased by 13.32% to VND7.21 trillion ($303.93 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw MSN of conglomerate Masan Group dropped 3.8%, followed by POW of electricity producer Petrovietnam Power Corporation with a 2.8% loss.
VCB of state-owned lender Vietcombank went down 2.5% and STB of Ho Chi Minh City-based lender Sacombank lost 2.3%.
Foreign investors were net sellers to the tune of VND126.53 billion, mainly selling HPG of steelmaker Hoa Phat Group and SSI of leading brokerage SSI Securities Corporation.
The HNX-Index at the Hanoi Stock Exchange, where mid and small caps list, was down 0.61% while the UPCoM-Index at the Unlisted Public Companies Market was down by 0.63%.