The index closed 8.73 points lower after losing 8.19 points on Thursday.
Trading on the Ho Chi Minh Stock Exchange (HoSE) fell by 11.50% to VND8.16 trillion ($346.13 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 20 tickers dropped.
VIB of Vietnam International Commercial Bank lost 4.5% and MWG of electronics retail chain Mobile World dropped 4.3%.
STB of Ho Chi Minh City-based lender Sacombank went down 3.3% and TPB of private TPBank fell 2.9%.
Six blue chips gained, led by VCB of state-owned lender Vietcombank with a 1.6% rise.
VNM of dairy giant Vinamilk went up 1.2%.
Foreign investors were net buyers to the tune of VND27.11 billion, mainly buying HPG of steelmaker Hoa Phat Group and GEX of electrical equipment maker Gelex Group.
The HNX-Index at the Hanoi Stock Exchange, where mid and small caps list, was down 1.14% while the UPCoM-Index at the Unlisted Public Companies Market was up by 0.12%.