The index closed 2.26 points lower after losing 14.79 points on Thursday.
Trading on the Ho Chi Minh Stock Exchange (HoSE) increased by 9.44% to VND10.29 trillion ($436.20 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 11 tickers drop.
PLX of fuel distributor Petrolimex and VHM of property giant Vinhomes both fell 2.6%.
VNM of dairy giant Vinamilk went down 2.5% and HPG of steelmaker Hoa Phat Group lost 2.2%.
Other decliners included VCB of state-owned lender Vietcombank, GAS of state-owned Petrovietnam Gas and MSN of conglomerate Masan Group.
Sixteen blue chips gained, led by VJC of budget airline Vietjet with a 6.8% surge.
HDB of HDBank went up 3.6% and NVL of property developer Novaland Group closed 3.1% higher.
Foreign investors were net buyers to the tune of VND615.55 billion, mainly buying SHB of Saigon Hanoi Commercial Bank and NVL.
The HNX-Index at the Hanoi Stock Exchange, where mid and small caps list, was up 0.14% while the UPCoM-Index at the Unlisted Public Companies Market was up by 0.54%.