The index closed 7.11 points higher after dropping 6.58 points in the previous session.
Trading on the Ho Chi Minh Stock Exchange increased by 22% to VND10.390 trillion (US$409.2 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 24 tickers gained.
MSN of conglomerate Masan Group rose 3.3%, VRE of retail real estate arm Vincom Retail closed 2.5% higher, and HDB of lender HDBank went up 2.4%.
Five blue chips fell. BCM of Becamex Investment and Industrial Development slid 1.1%, STB of Ho Chi Minh City-based lender Sacombank dropped 0.8%, and CTG of state-owned lender VietinBank fell by 0.5%.
Foreign investors were net seller to the tune of VND406 billion, mainly selling FPT of IT giant FPT Corporation and STB.
The HNX-Index for stocks on the Hanoi Stock Exchange, home to mid and small caps, rose 0.58%, while the UPCoM-Index for the Unlisted Public Companies Market went up 0.13%.
Globally, European shares opened higher on Wednesday due to broad-based gains as bond yields took a breather ahead of a crucial inflation reading in the United States, while British bourses outperformed following a soft local inflation reading, Reuters reported.
The pan-European STOXX 600 was up 0.3%, on track to snap a three-day losing streak.
UK's more domestically focussed midcap index jumped 1.4% after data showed British inflation unexpectedly slowed to an annual rate of 2.5% in December from 2.6% in November, with core measures of inflation falling more sharply.
The blue-chip FTSE 100 was last up 0.7%, outpacing European peers.