The index closed 0.93 points lower after dropping 3.05 points in the previous session.
Trading on the Ho Chi Minh Stock Exchange decreased by 7% to VND14.234 trillion (US$560.8 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 16 tickers fell.
VRE of retail real estate arm Vincom Retail saw the biggest decline of 1.9%, TPB of private lender TPBank went down 1.7%, and VHM of property giant Vinhomes dropped 1.3%.
Ten blue chips gained. PLX of fuel distributor Petrolimex closed 3.7% higher, BCM of Becamex Investment and Industrial Development gained 3.4%, and VJC of budget airline Vietjet increased by 2.2%.
Foreign investors were net seller to the tune of VND1.67 trillion, mainly selling HDB of lender HDBank and STB of Ho Chi Minh City-based lender Sacombank.
The HNX-Index for stocks on the Hanoi Stock Exchange, home to mid and small caps, fell 0.07%, while the UPCoM-Index for the Unlisted Public Companies Market went down 0.24%.