The index closed 1.06 points lower after gaining 7.04 points in the previous session.
Trading on the Ho Chi Minh Stock Exchange decreased by 2% to VND15.384 trillion (US$610.9 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 13 tickers fell.
VPB of private lender VPBank saw the biggest drop of 1.7%, followed by HPG of steelmaker Hoa Phat Group with a 1.1% decrease and CTG of state-owned lender VietinBank, down 0.8%.
Twelve blue chips gained. STB of Ho Chi Minh City-based lender Sacombank rose 2.7%, HDB of HDBank went up 1.5%, and VJC of budget airline Vietjet closed 1.1% higher.
Foreign investors were net seller to the tune of VND154 billion, mainly selling FUEVFVND of exchange-traded fund DCVFMVN DIAMOND and VHM of property giant Vinhomes.
The HNX-Index for stocks on the Hanoi Stock Exchange, home to mid and small caps, fell 0.40%, while the UPCoM-Index for the Unlisted Public Companies Market went down 0.02%.
Global shares edged higher on Friday, spurred by a rally in Chinese stocks on latest policy steps to boost demand and as robust U.S. economic data this week continued to bolster investor sentiment, Reuters reported.
MSCI's index of global stocks edged up a quarter of a percent, with tentative early gains for European stocks .
Mainland Chinese blue chips had closed up 3.6%, their biggest daily gain in eight sessions, after the country's central bank launched two schemes aimed at boosting stocks.