The index closed 4.51 points higher after gaining 9.87 points in the previous session.
Trading on the Ho Chi Minh Stock Exchange increased by 8% to VND18.471 trillion (US$743.4 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 14 tickers gained.
FPT of IT giant FPT Corporation closed 4.7% higher, followed by MSN of conglomerate Masan Group with a 3.9% increase and SAB of brewer Sabeco, up 2.3%.
Fourteen blue chips fell. STB of Ho Chi Minh City-based lender Sacombank slipped 1.6%, HPG of steelmaker Hoa Phat Group went down 0.91%, and TPB of lender TPBank decreased by 0.85%.
Foreign investors were net buyers to the tune of VND507 billion, mainly buying MSN and FPT.
The HNX-Index for stocks on the Hanoi Stock Exchange, home to mid and small caps, fell 0.21%, while the UPCoM-Index for the Unlisted Public Companies Market went up 0.14%.
Globally, European shares failed on Thursday to follow overnight gains in the U.S. and China, while the dollar sat near a two-month high before U.S. inflation data, Reuters reported.
Europe's broad Stoxx 600 index was down a whisker on the day, and the German 10 year bund yield, the euro zone benchmark nudged up to 2.27%, a five-week high, but the market focus was on gains in China spurred by hopes that a briefing this weekend will deliver anticipated fiscal stimulus.
China's blue-chip CSI300 index failed to hold all those gains, and the index closed up just over 1%, after the previous day's 7% fall, which was triggered by some investor concern about the lack of details in the stimulus package.
Hong Kong's Hang Seng surged over 3%, after slipping 1.3% on Wednesday and is up 26% this year.