The index closed 3.05 points lower after dropping 2.14 points in the previous session.
Trading on the Ho Chi Minh Stock Exchange decreased by 18% to VND15.253 trillion (US$600.1 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 9 tickers gained.
GVR of Vietnam Rubber Group grew 2.6%, VIC of private conglomerate Vingroup went up 1.6%, and VJC of budget airline Vietjet closed 1% higher.
Sixteen blue chips fell. MSN of conglomerate Masan Group saw a 1.32% drop, followed by BVH of insurance company Bao Viet Holdings with a 1.3% decline and HPG of steelmaker Hoa Phat Group, down 1.2%.
Foreign investors were net seller to the tune of VND762 billion, mainly selling VHM of property giant Vinhomes and MWG of electronics retail chain Mobile World.
The HNX-Index for stocks on the Hanoi Stock Exchange, home to mid and small caps, fell 0.15%, while the UPCoM-Index for the Unlisted Public Companies Market went down 0.19%.