The index closed 4.69 points lower after dropping 13.49 points in the previous session.
Trading on the Ho Chi Minh Stock Exchange decreased by 14% to VND13.784 trillion (US$543.2 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 19 tickers fell.
GVR of Vietnam Rubber Group saw the biggest fall of 2%, followed by MSN of conglomerate Masan Group with a 1.66% drop and POW of electricity producer Petrovietnam Power Corporation, down 1.65%
Four blue chips gained, including VPB of private lender VPBank with a 0.5% increase and MWG of electronics retail chain Mobile World, up 0.2%.
STB of Ho Chi Minh City-based lender Sacombank rose 0.2% and VCB of state-owned lender Vietcombank closed 0.1% higher.
Foreign investors were net seller to the tune of VND413 billion, mainly selling MSN and DGC of Duc Giang Chemicals Group.
The HNX-Index for stocks on the Hanoi Stock Exchange, home to mid and small caps, fell 0.03%, while the UPCoM-Index for the Unlisted Public Companies Market went down 0.27%.
Global stocks were set to end the week lower as looming U.S data and Japan's weekend election curbed a rally already knocked off course by the close-run race for the White House and expectations the Federal Reserve will resist rapid rate cuts, Reuters reported.
MSCI's broad world equity index was steady on Friday but heading for a 1.2% slide on the week, its first weekly loss of the month, while European shares also started the day 0.2% lower.
Japan's Nikkei dropped 0.7% on Friday and the yen was steady at 151.87 per dollar after Japanese officials warned speculators off betting against the currency, which has weakened rapidly from around 141 in mid-September.
Elsewhere in Asia Hong Kong's Hang Seng rose 0.5% and mainland Chinese shares added 0.7%