"We continue to see local transmission of mpox clade II here in the Philippines, in Metro Manila in particular," Health Minister Teodoro Herbosa said in a statement.
The newly confirmed cases were a 37-year-old male in Metro Manila who had rash on his body last week and was brought to a government hospital, and a 32-year-old male from the capital who had skin lesions on his body.
The Philippines announced last week it had detected a case of the mpox virus' milder variant in a 33-year-old male who had no travel history outside the Philippines.
The three cases this year means the Philippines has had 12 laboratory-confirmed case since July 2022.
The World Health Organization earlier this month declared mpox a global public health emergency, its highest form of alert, for the second time in two years, because of an outbreak in the Democratic Republic of Congo that had spread to neighbouring countries.
A new form of the virus has triggered global concern as it seems to spread easily though routine close contact.
The disease, caused by the monkeypox virus, leads to flu-like symptoms and pus-filled lesions. It is usually mild but can kill, with children, pregnant women and people with weakened immune systems, such as those with HIV, all at higher risk of complications.