The early signs, however, are that they may need to wait a little longer.
Thailand, one of Asia's most popular tourist destinations, has enforced strict entry curbs during the past 18 months, but from Monday allowed vaccinated travellers from more than 60 countries to visit without having to quarantine.
"Khaosan Road is Bangkok's landmark for foreign visitors. For us all business owners, they are our hope," Thapanee Pansodsaicharoenkit, owner of the 'Rocco' restaurant, told Reuters on Tuesday.
When Reuters visited on Tuesday evening there were a few people visiting the restaurants and bars, but the street remained quiet, with around 90 percent of shops closed indefinitely.
Business along the Khaosan Road has been on pause for the past 18 months, Prasit Singhdamrong, president of Khaosan Business Association, told Reuters by phone, with only 10 percent of businesses able to remain open.
Restaurants certified by the tourism authorities can serve alcohol until 9 p.m. but bars will remain closed, the Bangkok Metropolitan Authority said in a statement Saturday.
"Khaosan is not a place where people come to eat, because we're not Michelin-star eateries," said Prasit.
"I think it won't be long for tourists to fill the street again, unless there's another outbreak," said 36-year-old Papot Meecharoen, as he waited for customers at his hair braiding stall.