Globally, Japan ranked ninth in the list, topped by the Netherlands and Australia.
The company surveyed American travelers about the places in Asia they visited and how safe they felt, then paired those insights with data from the Global Peace Index, Numbeo, and GeoSure.
Japan's strong standing in safety could stem from several factors, including societal structure, strict laws, and cultural focus on harmony, which keep street crime and public disturbances very low, the report said.
That sense of security allows travelers to focus less on caution and more on experiencing everything the country has to offer.
In Tokyo, travelers can explore the bustling neighborhoods of Shibuya, Harajuku, and Shinjuku, admire cutting-edge architecture, stroll through peaceful Japanese gardens, and experience vibrant nightlife without worrying about personal safety, Travel+Leisure magazine wrote.
Japan, named the "world's most favorite destination" this year by readers of Condé Nast Traveler, welcomed an estimated 39.06 million foreign visitors from January to November, surpassing last year's record of 36.87 million.