The resort has Indochina-inspired designs with mosaic tiles, statues on plinths, clawfoot bathtubs, and leather-bound tables.
Its 127 rooms feature original paintings by Vietnamese artists about the country and woodwork made by local craftsmen.
Room rates start at US$260 a night.
Mui Ne, a beach resort town in the south central coast famous for its adventure sports, enjoys a warm climate year round and has become a favorite destination for Western tourists in recent years.
The CNN list also included Punakha River Lodge in Bhutan, Emerald Faarufushi Resort & Spa in the Maldives, Shinta Mani Mustang in Nepal, and Hoshino Resort KAI Yufuin in Japan.