The epicenter HCMC recorded 1,662 cases, while its neighbors Binh Duong recorded 820 cases and Dong Nai 575 cases.
105 deaths were added to the national database on Saturday: 74 in Ho Chi Minh City, 18 in Binh Duong, five in An Giang, three in Dong Nai, two in Tay Ninh and one in Hanoi.
The total number of coronavirus deaths so far is 20,442, taking up around 2.4 percent of all infections.
1,319 Covid-19 patients were announced recovered, bringing the total number of recovered cases to 760,801.
Vietnam has vaccinated over 37.7 million with at least one Covid-19 vaccine shot. Over 14.2 million people have been fully vaccinated.
With coronavirus cases dropping in many localities including HCMC, the Ministry of Transport has decided to restart daily flights on 19 routes including the one between Hanoi and HCMC from Sunday.
Arrivals from HCMC to Hanoi will have to stay in centralized quarantine for a week.