The index closed 4.07 points lower after dropping 13.43 points in the previous session.
Trading on the Ho Chi Minh Stock Exchange decreased by 20% to VND14.68 trillion ($605 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 17 tickers fell.
SAB of brewer Sabeco dropped 1.6%, followed by STB of Ho Chi Minh City-based lender Sacombank, down 1.3%.
MSN of conglomerate Masan Group fell 1.2% and HPG of steelmaker Hoa Phat Group closed 1.1% lower.
Seven blue chips gained, led by FPT of IT giant FPT Corporation with a 1.1% rise.
Foreign investors were net sellers to the tune of VND358 billion, mainly selling CTG of state-owned lender VietinBank and STB of Ho Chi Minh City-based lender Sacombank.
The HNX-Index for stocks on the Hanoi Stock Exchange, home to mid and small caps, fell 0.52%, while the UPCoM-Index for the Unlisted Public Companies Market went up 0.10%.