The index closed 2.43 points higher after gaining 2.75 points on Tuesday. It remains at the highest since Sep. 27.
Trading on the Ho Chi Minh Stock Exchange (HoSE) fell by 13.26% to VND16.60 trillion ($700.85 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 14 tickers gain.
PDR of Phat Dat Real Estate Development led with a 3.8% increase, followed by BVH of insurance company Bao Viet Holdings, up 3%.
VRE of retail real estate arm Vincom Retail went up 2.9% and VHM of property giant Vinhomes closed 2.2% higher.
Fifteen blue chips fell.
VPB of private lender VPBank dropped 1.3% and HPG of steelmaker Hoa Phat Group fell 1.1%.
Foreign investors were net sellers to the tune of VND440.56 billion, mainly selling STB of Ho Chi Minh City-based lender Sacombank and DGC of Duc Giang Chemicals Group.
The HNX-Index at the Hanoi Stock Exchange, where mid and small caps list, was down 0.15% while the UPCoM-Index at the Unlisted Public Companies Market was down by 0.05%.