The index closed 2.71 points higher after gaining 18.35 points on Monday.
Trading on the Ho Chi Minh Stock Exchange (HoSE) increased by 11.24% to VND21.99 trillion ($909.71 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 13 tickers gained.
BCM of Becamex Investment and Industrial Development and VPB of private lender VPBank led, both with a 2.7% rise.
MWG of electronics retail chain Mobile World went up 2.3% and GVR of Vietnam Rubber Group closed 2.2% higher.
Fourteen blue chips fell. VIC of private conglomerate Vingroup dropped 2% and VRE of retail real estate arm Vincom Retail fell 1.7%.
Foreign investors were net sellers to the tune of VND205.98 billion, mainly selling SSI of leading brokerage SSI Securities Corporation.
The HNX-Index at the Hanoi Stock Exchange, where mid and small caps list, was up 0.65% while the UPCoM-Index at the Unlisted Public Companies Market was up by 0.69%.