The index closed 4.53 points lower after dropping 5.36 points in the previous session.
Trading on the Ho Chi Minh Stock Exchange increased by 3% to VND15.51 trillion ($630.17 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 23 tickers fell.
MWG of electronics retail chain Mobile World dropped 2.2%, followed by MSN of conglomerate Masan Group with a 1.9% decline.
TPB of private TPBank went down 1.6% and ACB of Asia Commercial Bank closed 1% lower.
Seven blue chips bucked the trend but with marginal gain. SHB of Saigon Hanoi Commercial Bank and STB of Ho Chi Minh City-based lender Sacombank led, both with a 0.8% gain.
Foreign investors were net buyers to the tune of VND85 billion, mainly buying SSI of leading brokerage SSI Securities Corporation and EIB of private lender Eximbank.
The HNX-Index for stocks on the Hanoi Stock Exchange, home to mid and small caps, fell 0.32%, while the UPCoM-Index for the Unlisted Public Companies Market went up 0.22%.