It dropped 1.66 points after losing 2.36 points Thursday.
Trading on the Ho Chi Minh Stock Exchange (HoSE), on which the index is based, gained 6.3% to VND26.34 trillion ($1.09 billion).
The VN30 basket, comprising the 30 largest capped stocks, saw 17 tickers fell.
VIC of private conglomerate Vingroup dropped 2.8%, followed by VRE of retail real estate arm Vincom Retail with a 2.3% decline.
VHM of property giant Vinhomes fell 2% and STB of Ho Chi Minh City-based lender Sacombank closed 1.5% lower.
Twelve blue chips gained, led by BCM of Becamex Investment and Industrial Development with a 2.3% rise.
Foreign investors were net buyers to the tune of VND99 billion, mainly buying VPB of private lender VPBank and VNM of dairy giant Vinamilk.
The HNX-Index for stocks on the Hanoi Stock Exchange, home to mid and small caps, was up 0.02% while the UPCoM-Index for the Unlisted Public Companies Market also closed 0.02% higher.