The index closed 4.5 points lower after losing 1.6 points on Thursday.
Trading on the Ho Chi Minh Stock Exchange (HoSE) fell by 2.8% to VND14.92 trillion ($637.53 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 22 tickers dropped.
HDB of HDBank dropped 2.1%.
CTG of state-owned lender VietinBank and HPG of steelmaker Hoa Phat Group both fell 1.7%.
Other losers included FPT of IT giant FPT Corporation, VHM of real estate giant Vinhomes and KDH of real estate firm Khang Dien House.
Six blue chips gained, led by VPB of private lender VPBank with a 4% rise.
GAS of state-owned Petrovietnam Gas gained 1.7%, and VNM of dairy giant Vinamilk rose 1%.
Foreign investors were net sellers to the tune of VND102.28 billion.
The HNX-Index at the Hanoi Stock Exchange, where mid and small caps list, was down 1.08% while the UPCoM-Index at the Unlisted Public Companies Market was down by 0.09%.