The index closed 0.44 points lower after gaining 1.62 points on Thursday. It dropped 34.21 points on Wednesday.
Trading on the Ho Chi Minh Stock Exchange (HoSE) fell by 2.36% to VND10.79 trillion ($460.13 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 16 tickers dropped.
NVL of property developer Novaland Group went up 5.3% after the company announced that former billionaire Bui Thanh Nhon will return as chairman.
It was followed by distributor Petrolimex and VIB of Vietnam International Commercial Bank, both went up 3%.
SAB of brewer Sabeco gained 2.8% and VCB of state-owned lender Vietcombank increased by 2.6%.
Sixteen blue chips fell.
MWG of electronics retail chain Mobile World dropped 4.2% and TCB of the largest private lender Techcombank lost 3.2%.
Foreign investors were net buyers to the tune of VND530.15 billion, mainly buying STB of Ho Chi Minh City-based lender Sacombank and HPG of steelmaker Hoa Phat Group.
The HNX-Index at the Hanoi Stock Exchange, where mid and small caps list, was down 0.01% while the UPCoM-Index at the Unlisted Public Companies Market was up by 0.88%.