The index closed 3.38 points lower after losing 10.56 points on Wednesday.
Trading on the Ho Chi Minh Stock Exchange (HoSE) fell by 22% to VND7.87 trillion ($316.51 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 16 tickers dropped.
NVL of real estate developer Novaland Group hit the floor with a 6.9% drop.
PDR of Phat Dat Real Estate Development fell 3.6%, and HDB of HDBank dropped 2.7%.
Other decliners included VJC of budget airline Vietjet, ACB of Asia Commercial Bank and BID of state-owned lender BIDV.
Twelve blue chips gained, led by MSN of conglomerate Masan Group with a 5.4% rise and MWG of electronics retail chain Mobile World, up 3.1%.
Other rising stocks include TCB of the largest private lender Techcombank, VNM of dairy giant Vinamilk and STB of Ho Chi Minh City-based lender Sacombank.
Foreign investors were net buyers to the tune of VND251.2 billion, mainly selling HPG and CTG of state-owned lender VietinBank.
The HNX-Index at the Hanoi Stock Exchange, where mid and small caps list, was down 0.43% while the UPCoM-Index at the Unlisted Public Companies Market was down by 0.46%.