The index closed nearly 2 points lower after gaining 17 points on Thursday.
Trading on the Ho Chi Minh Stock Exchange (HoSE) fell by 2 percent to VND15.03 trillion ($643.77 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 15 tickers rise.
SAB of brewer Sabeco rose 4 percent to the highest since March 2021.
BID of state-owned lender BIDV gained 2.2 percent to a near three-month high.
Other gainers included VHM of real estate giant Vinhomes, up 1.9 percent, and VCB of state-owned lender Vietcombank, up 1.6 percent.
Fifteen blue chips fell, with VIC of biggest private conglomerate Vingroup falling 4.5 percent.
MSN of conglomerate Masan Group lost 3.5 percent, and TPB of private TPBank fell 2.2 percent.
Foreign investors were net sellers to the tune of VND5.94 billion, mainly selling NVL of real estate developer Novaland Group and ACV of Airports Corporation of Vietnam.
The HNX-Index at the Hanoi Stock Exchange, where mid and small caps list, was down 0.42 percent while the UPCoM-Index at the Unlisted Public Companies Market was up by 0.12 percent.