The index closed 27.95 points lower after losing 4.46 points on Tuesday.
Trading on the Ho Chi Minh Stock Exchange (HoSE) increased by 7.40% to VND12.74 trillion ($535.58 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw all tickers dropped.
NVL of property developer Novaland Group hit the floor with a 6.6% decline.
PDR of Phat Dat Real Estate Development fell 6%, and PLX of fuel distributor Petrolimex lost 5.9%.
VHM of property giant Vinhomes dropped 5.8% and SSI of leading brokerage SSI Securities Corporation went 5.6% lower.
Foreign investors were net sellers to the tune of VND364.15 billion, mainly selling VIC of private conglomerate Vingroup and VHM.
The HNX-Index at the Hanoi Stock Exchange, where mid and small caps list, was down 1.92% while the UPCoM-Index at the Unlisted Public Companies Market was down by 0.93%.