With the new facility, Vietnam has now gone beyond its role as a global production hub for Samsung and become a strategic base for major research and development, the company said at the opening ceremony.
Construction of the 16-story facility began in March 2020.
Prime Minister Pham Minh Chinh said at the event that Samsung's opening of the R&D Center in Vietnam is a testament to its orientation and commitment to long-term operation in Vietnam.
"Samsung is the largest foreign investor in Vietnam with total registered investment of nearly $20 billion."
He added that its effective operation has made important contributions to Vietnam in terms of exports, jobs and taxes.
Tae-Moon Roh, Samsung Electronics president, hoped the center would nurture the best Vietnamese talent.
Samsung established its first smartphone factory in Vietnam in 2008 and has invested $18.2 billion so far. The figure could rise to $20 billion by the end of this year.
Around half of all Samsung smartphones are made in Vietnam.