The index closed three points lower after gaining nearly 20 points Thursday. It has lost nearly 32 points this week.
Trading on the Ho Chi Minh Stock Exchange increased by 0.2 percent to VND10.18 trillion ($437.71 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 14 tickers drop.
POW of electricity producer Petrovietnam Power Corporation fell 2.5 percent, while GAS of state-owned Petrovietnam Gas dropped 2.4 percent.
Other losers included HDB of HDBank, down 2.1 percent, CTG of state-owned lender VietinBank, down 2 percent, and TPB of private TPBank, down 1.9 percent.
Thirteen blue chips gained, led by BVH of insurance company Bao Viet Holdings with a 4 percent rise.
It was followed by SAB of brewer Sabeco, up 1.4 percent, and PNJ of Phu Nhuan Jewelry, up 1.2 percent.
Foreign investors ended three sessions of buying with a net sale of VND82 billion, mainly selling NVL of real estate developer Novaland Group and HPG of steelmaker Hoa Phat Group.
The HNX-Index at the Hanoi Stock Exchange, where mid and small caps list, was down 0.45 percent while the UPCoM-Index at the Unlisted Public Companies Market was up by 0.46 percent.