The index closed 1.45 points lower after dropping 13.32 points in the previous session.
Trading on the Ho Chi Minh Stock Exchange decreased by 17% to VND15.556 trillion (US$612.1 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 14 tickers fell.
PLX of fuel distributor Petrolimex slipped 1.8%, MWG of electronics retail chain Mobile World went down 1.7%, and VJC of budget airline Vietjet closed 1.5% lower.
Twelve blue chips gained. TPB of private TPBank went up 2.6%, SSI of brokerage SSI Securities Corporation rose by 1.5%, and VHM of property giant Vinhomes saw a 1.4% increase.
Foreign investors were net seller to the tune of VND1.45 trillion, mainly selling MWG and SSI.
The HNX-Index for stocks on the Hanoi Stock Exchange, home to mid and small caps, rose 0.12%, while the UPCoM-Index for the Unlisted Public Companies Market went up 0.33%.
Global shares were mostly lower on Monday, with investors waiting for Nvidia's earnings release later in the week, Reuters reported.
MSCI's broadest gauge of world stocks was down 0.1%, while the pan-European STOXX 600 was off 0.2%. Major indexes in Frankfurt, London and Paris were down 0.1% to up 0.2%.
In Asia, MSCI's broadest index of Asia-Pacific shares outside Japan advanced 0.2%. Japan's Nikkei 225 fell 1.1%, dragged down by a decline in technology shares.