The index closed 5.95 points higher after gaining 19.69 points in the previous session.
Trading on the Ho Chi Minh Stock Exchange increased by 37% to VND18.546 trillion (US$752.6 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 17 tickers gained.
CTG of state-owned lender VietinBank went up 2.1%, SSI of brokerage SSI Securities Corporation saw a 2.1% growth, and MWG of electronics retail chain Mobile World closed 2.1% higher.
Nine blue chips fell. VRE of retail real estate arm Vincom Retail closed 1.3% lower, SAB of brewer Sabeco declined by 0.7%, and HPG of steelmaker Hoa Phat Group went down 0.6%.
Foreign investors were net buyers to the tune of VND312 billion, mainly buying FPT of IT giant FPT Corporation and SSI.
The HNX-Index for stocks on the Hanoi Stock Exchange, home to mid and small caps, rose 0.28%, while the UPCoM-Index for the Unlisted Public Companies Market went up 0.30%.
Globally, the dollar slipped on Wednesday while Treasury yields edged higher and global stocks steadied as traders weighed the odds of a super-sized Federal Reserve interest rate cut later in the day, Reuters reported.
The MSCI's index of world stocks was flat after having touched a two-week high a day earlier and just below an all-time high.
European stocks slipped 0.3%, with technology and healthcare shares among the biggest laggards.
Japan's Nikkei stock index climbed as much as 1.3% early on in reaction to overnight weakness in the yen, but pared those gains to 0.5% as the currency rebounded.
Wall Street finished nearly unchanged on Tuesday, failing to sustain early momentum that pushed the S&P 500 and Dow Jones to record intraday highs. S&P 500 futures pointed a flat open later on Wednesday.