The index closed 11.39 points higher after dropping 11.97 points in the previous session.
Trading on the Ho Chi Minh Stock Exchange increased by 34% to VND17.802 trillion (US$700,5 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 24 tickers gained .
BCM of Becamex Investment and Industrial Development saw the biggest rise of 2.7%, followed by VHM of property giant Vinhomes with a 2.6% increase and TCB of private lender Techcombank, up 2.0%.
Two blue chips fell. MWG of electronics retail chain Mobile World slid 1.2% and GAS of state-owned Petrovietnam Gas went down 0.4%.
Foreign investors were net seller to the tune of VND1.209 trillion, mainly selling FPT of IT giant FPT Corporation and VHM.
The HNX-Index for stocks on the Hanoi Stock Exchange, home to mid and small caps, rose 0.73%, while the UPCoM-Index for the Unlisted Public Companies Market went up 0.80%.
Globally, Europe's main stock index opened higher on Wednesday after a three-session decline, as construction and bank stocks led an overall market recovery, with most safe-haven bids taking a backseat amid easing geopolitical concerns, Reuters reported.
The pan-European STOXX 600 was up 0.6% after touching a three-month low on Tuesday amid an investor rush to safe-haven assets.
The Swiss franc and U.S. government bond prices dipped, while the dollar touched a one-week low in intraday trade.
Meanwhile, UK stocks underperformed regional peers after domestic inflation came in above the 2% target last month, underscoring the Bank of England's cautiousness on rate cuts.