The index closed 0.06 points lower after gaining 0.14 points in the previous session.
Trading on the Ho Chi Minh Stock Exchange decreased by 0.62% to VND13 trillion (US$519.2 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 17 tickers gained.
VRE of retail real estate arm Vincom Retail went up 1.9%, SAB of brewer Sabeco rose by 1.7%, and VHM of property giant Vinhomes closed 1.6% higher.
Thirteen blue chips fell. VCB of state-owned lender Vietcombank slid 2.1%, SSI of brokerage SSI Securities saw a 1.7% decline, and MBB of lender MBBank fell 1.5%.
Foreign investors were net buyers to the tune of VND664 billion, mainly buying KDC of food producer KIDO Group and MSN of conglomerate Masan Group.
The HNX-Index for stocks on the Hanoi Stock Exchange, home to mid and small caps, fell 0.22%, while the UPCoM-Index for the Unlisted Public Companies Market went down 0.15%.
Globally, European shares rose in early trade on Wednesday after data pointing to softer inflation helped markets recover from last week's meltdown, while traders hoped that U.S. inflation data later in the session would also be benign, Reuters reported.
The Japanese yen and the Nikkei wobbled after Japan's Prime Minister Fumio Kishida said he will step down next month, but Asian shares still rose overall as markets recovered from the recent rout.
The MSCI World Equity index was up 0.3% on the day, at its highest in 12 days.
Europe's STOXX 600 was up 0.4% on the day while London's FTSE 100 was up 0.5% after data showed British inflation rose less than expected in July.