The index closed 6.32 points lower after dropping 9.09 points in the previous session.
Trading on the Ho Chi Minh Stock Exchange increased by 2% to VND25.85 trillion ($1.02 billion).
The VN-30 basket, comprising the 30 largest capped stocks, saw 22 tickers fell.
VIC of private conglomerate Vingroup dropped 2.8%, followed by VRE of retail real estate arm Vincom Retail with a 2.5% decline.
MBB of lender MB lost 2%.
Eight blue chips gained. The top gainers included MWG of electronics retail chain Mobile World, up 3.8% and GVR of Vietnam Rubber Group, up 3.2%.
Foreign investors were net seller to the tune of VND1.35 trillion, mainly selling FPT of IT giant FPT Corporation and MBB of lender MB.
The HNX-Index for stocks on the Hanoi Stock Exchange, home to mid and small caps, fell 0.06%, while the UPCoM-Index for the Unlisted Public Companies Market went down 0.13%.