It was the only Southeast Asian city to make the list, with the report highlighting its "strict enforcement of laws."
The city-state is known for its stringent cleanliness regulations, with no-littering signs visible throughout. First-time offenders can face fines of up to S$1,000 (US$761), while repeat violators may be fined up to S$2,000 and assigned Corrective Work Orders as a penalty.
Singapore's exceptional safety measures include extensive surveillance cameras in downtown areas and frequent police patrols in popular tourist spots.
Theft is a serious offense in the city-state, carrying penalties of fines and/or imprisonment for up to three years.
Reykjavík, the capital of Iceland, topped the list as the world's safest city, followed by Copenhagen and Amsterdam. Others are Tokyo, Sydney, Montreal, Seoul, Berlin, Hong Kong, Venice, London, Honolulu, Dubai and Barcelona.
To compile the rankings, the company selected 31 of the most popular international and domestic cities for U.S. travelers based on sources such as Expedia, USA Today, and Forbes.
More than 1,500 survey respondents who had personally visited these cities were asked to rank them based on various safety measures, using their firsthand experiences as a reference.