Served by seven carriers, it also has the lowest average economy fare among the top 10 at just US$62 one-way, highlighting intense competition, OAG said.
The route connecting two of Asia's largest hubs and popular tourist destinations takes nearly one hour.
Hong Kong-Taipei continued to be the world's busiest international route this year with 6.8 million seats, followed by Cairo-Jeddah route.
Seoul Incheon and Tokyo Narita route ranked fourth with 5 million seats, followed by Seoul Incheon- Osaka Kansai route with 4.9 million seats.
The rest of top 10 were Jakarta - Singapore Changi, Dubai - Riyadh, Bangkok - Hong Kong, Tokyo Narita - Taipei and New York JFK - London Heathrow.