Their mainstay at the back, national player Do Duy Manh, suffered a minor injury in a V. League game and his participation is in doubt.
The other center-backs, Dinh Tien Thanh and Dau Van Toan, are already out with injuries.
Doan Van Hau, who can play at both center-back and left-back, damaged a knee in a league game and is out for five weeks.
Right-back Tran Van Kien has also had problems with a foot.
Head coach Chu Dinh Nghiem admitted to being concerned at the pre-match press conference.
"What I’m worried about most right now is that players are burning out and [will be exhausted] for the game."
"Two-thirds of the team are burning out. Pape Omar is having an ankle issue. I have talked with Duy Manh to see if he can play. We have no more centre-backs left. Manh can play, but not for 90 minutes."
The team’s injury problems are not only at the back. Striker and captain Nguyen Van Quyet is not sure about taking the field either.
Hanoi FC seems set for a hard time despite playing at home at the Hang Day Stadium.
The game kicks off at 7 p.m. on August 20, and will be reported live by VnExpress.