Hundreds of people were dancing to the music at the Ferso bar in District 3 past midnight when HCMC police officers entered the premises.
Many people tried to escape and threw away plastic bags. Several narcotic pills and bags containing crystals were found at the scene.
A quick test revealed that 74 customers and 14 bar employees tested positive for narcotics.
Police have filed a report to punish the bar for late opening and letting customers use drugs, although specific penalties were not revealed.
Around two months prior, the Ferso bar was also raided by police, with 78 people testing positive for drugs at that time.