The index closed 13.32 points lower after dropping 14.15 points in the previous session.
Trading on the Ho Chi Minh Stock Exchange increased by 16% to VND18.648 trillion (US$734.4 million).
The VN-30 basket, comprising the 30 largest capped stocks, saw 26 tickers fell.
SSI of brokerage SSI Securities Corporation saw the biggest drop of 3.0%, followed by MWG of electronics retail chain Mobile World with a 2.3% decline and HDB of of lender HDBank, down 2.2%
Only three blue chips gained, including VRE of retail real estate arm Vincom Retail with a 0.6% increase, SSB of SeABank, which closed 0.3% higher, and BVH of insurance company Bao Viet Holdings, up 0.1%.
Foreign investors were net seller to the tune of VND1.316 trillion, mainly selling VHM of property giant Vinhomes and ACB of Asia Commercial Bank.
The HNX-Index for stocks on the Hanoi Stock Exchange, home to mid and small caps, fell 1.02%, while the UPCoM-Index for the Unlisted Public Companies Market went down 0.62%.
Globally, Asian shares looked to end a brutal week on a steadier note on Friday, helped by Chinese data showing retail sales in the world's second-biggest economy beat forecasts in October in a welcome sign for consumer spending, although other indicators missed, Reuters reported.
MSCI's broadest index of Asia-Pacific shares outside Japan rose 0.4% but was still down 4.1% for the week, its biggest weekly loss since June 2023.
A regional healthcare index underperformed with a drop of 0.7%, after U.S. President-elect Donald Trump nominated Robert F. Kennedy Jr., a prominent vaccine sceptic, to lead the top U.S. health agency.
Tokyo's Nikkei, however, gained 0.7% driven by a pull back in the yen, which boosted the outlook for Japanese exporters. Still, it was down 1.7% for the week.
Chinese shares trimmed earlier losses as official data showed retail sales rose by a better-than-expected 4.8% in October, but growth in industrial output missed forecasts and declines in property investment deepened.
China's blue chips were last down 0.2% while Hong Kong's Hang Seng index rose 0.5%.